The cards the players place in their 1st rows at the start of the game have a great influence on the game. One or two high strength cards in the 1st row is a good idea, but a player who loses his strongest cards early in the game is in a weak position.
Although challenges can occur as early as the second round, a player is often better served to build up his forces on his side of playing field before initiating challenges.
From the 1st row, Medusa protects the cards in her column, but she reduces the player's ability to challenge his opponent's cards.
Pegasus can be used to uncover the opponent's face-down cards. Also, Pegasus is the only way to defeat Hera and Zeus.
By holding the hostage card (Io or Argus) in his hand, a player can keep it off the playing field and postpone its rescue, but Pegasus can still find it in his hand either directly or by finding Pandora there.
By playing Hera or Zeus, a player can strengthen a weak 1st row, but this is often not a good strategy early in the game.
The cards with mythological symbols are powerful, but when played from a player's hand, as most must be, they are immediately discarded and, thus, have only that instant effect.
Hero and Amazon can be important weapons against Medusa at the end of the game.
Pandora, with her dangerous box (the name says it all), is a very unpredictable card.
Games often end when a player cannot use all his action points.